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Raising the minimum hours required to work at a 121 carrier is only one small part of what needs to take place to put things right in this industry. However it is a step in the right direction in that it at least attempts to force the airlines to hire pilots with more experience. It's certainly not a perfect solution, but again the airlines have made it quite clear they'd be content with a fresh commercial pilot in the left seat and a private pilot riding as an apprentice in the right seat (forgive me a bit of hyperbole). A limit has to be set somewhere, and the carriers have made it abundantly clear they are not willing to do so voluntarily.
Excellent post-- it is all about establishing some kind of minimal floor. Quite apart from experience, to the extent that a floor modifies the supply of regional fodder even a little bit, pay and work rules will be improved, which will benefit safety. Also badly needed is legislation that prevents those companies, whose logos and names appear on regional hulls and the passengers tickets and boarding passes, from using a few sentences of fine print to whitewash themselves of any liability from their regional partners. Shared liability for accidents would trigger more safety audits and hopefully more mentoring of their regional partners operating procedures, as well as training programs.