Skaff, I would most definitely make the jump. I can only speak from my experiences, but as good as ACA was, it was still a regional with that dreaded "regional mentality." You know, always wondering whose flying we'll do next, the RJ debate, that "second class citizen" status we carried around us, the shoddy IAD operation, etc. When I jumped ship to a major, the differences were appalling to say the least. Now, this was a good seven years ago when we didn't have the problems we did today, but still..... you have to realize that the problems we have today have been happening every decade or so - with the exception of dissapearing pension plans. (My airline, AA still has it but I'm sure it'll be up for discussion in this next contract.)
That said, you have to make the jump for the right reasons. If you just have big jet envy and screw the rest, something tells me you won't be too happy. You have to do it as a long term investment - because jumping to a major WILL pay off long term compared to a regional, several thousand dollars' worth if not a million or more. And you have to do it with two things in mind, days off and quality of life. Those two things are the only things you will worry about long term because believe me, big jet syndrome does not last long at all. In the end, it's all about good time off and good flexible work rules that allow you to maximize your time off while preserving maximum pay. That is the payoff for all that time away from home.
And while $100K is indeed good money for a regional, that's only third year pay at a couple of majors, and not that far off for the rest, while still F/O. When you make CA, you'll be looking at $125-150K as a minimum, depending on the airline. As you can see, the ROI pays off after a few years. Granted, it'll take you a few years to catch up with what you're making now - but like I said, if you're in a position to do it, it'll pay off long term.
good luck w/ your decision,
73