The Seneca II does fine with two up front and no one in the rear. I flew many hours in the Seneca II and III with two on board in the front seats, always within CG.
As for single engine missed approaches in them, no. I once told an FAA inspector "no" when he insisted on doing them during a 135 checkride in the airplane. He told me he'd fail me for refusing to do one. I told him he didn't have a legal leg to stand on, and asked him if he'd like to get out now, or wait until we got back to the airport. He grumbled and said carry on...we did the ride without the missed approach on one (which he can't require in a Part 23 airplane...it's not certified to do so or required to be able to do it).
I did the same thing during a checkride in a King Air 90, and warned the examiner/chief pilot not to pull the engine. He did it anway, and despite having been warned that he wouldn't get the engine back if he pulled it, he gave it a shot. When he learned I was setting up to put the airplane in a field because that was the only option at the time, he demanded, then begged for the power...and was in tears before I let him have it back.
Ride passed...chief pilot educated.
I'd have given him more of a pass if he hadn't tried to insist he'd have done the single engine missed out of a high density altitude airport in the mountains, with passengers on board...in front of the company general manager.
In a light twin like a Seneca II or a Cessna 310, if a missed is required, I won't do it. I'll land between the runways, on a taxiway, after or before the problematic traffic etc...and I'd never teach a student to develop the mentality of taking one around on one engine, either. Bad, bad move.