As an example, I'm showing our CJ2+ from CPS-SJC to be 4+39 and 3600lb block fuel burn...cruising at FL450 with 46kt average headwind. Our Fltplan.com profile is a little conservative on fuel burns, so we'd probably be closer to 3400lb burn...but 600lb is just 45min legal IFR reserves and I wouldn't plan to land that short on fuel.
If you were to fly at a constant long-range speed of 0.68M (vs. the 0.737M max), you'd probably shave another 100-150lbs off that.
Either way, its highly doubtful the 2+ could make St. Louis-Bay Area westbound even under the best circumstances, and the CJ3 would be limited doing so against stiff winds (and even more so with your payload).
If your boss HAS to go west-coast nonstop, the LR45 is definitely your airplane...if he can live with 2x monthly westbound tech stops the CJ series will fit the rest mission profile more efficiently.