When I flew for a regional I felt burnt out. I was working up to 20 days a month and I was making just under $100k/year. I wanted to move up to a major and start making more per hour, so I could work fewer hours/days and maintain the same standard of living. Now that I'm on reserve at a major, I wish I flew a little more. Don't get me wrong, I love being home with my family. The only thing better than getting paid to fly is getting paid not to fly. The last six month I've been averaging fewer than 40 hours per month, working about two days per week.
Like PooPooPants mentioned, great overnights in small towns are great. I had some of the best times of my life flying for a regional. Luckily, my major feels like a regional sometimes and I'm able to experience some of those small town overnights.
Pilots and flight attendants tend not to stick together for a week, so there's a little more anonymity at the majors. I feel like every trip I'm sitting next to a new pilot, and every leg I'm flying with new flight attendants. Crews at my airline are definitely less social than they were at my regional. Then again, at the regional you're more likely to have an entire crew under 30, or even under 25.
This month marks my 10th anniversary flying for the airlines and I still love it. I think this past decade has taught me to manage my expectations. This industry has seen a lot of change. The pilots that are the biggest complainers have the most to complain about. I'd probably have a little trouble loving this job if I'd moved from airline to airline, been furloughed, or if it had led me to lose my wife or my house. I've been lucky enough to have flown for two profitable airlines and my pay, except for my first 2 years at the major has mostly gone up.
To quote my a jumpseater last week, "we still want to make a million dollars and management still wants us to do it for free."
I guess I talked about pay and QOL, but it's hard to ignore when it's such a big part of our career. Plus it varies so widely throughout the industry.
I think most people that frequent this board either love the job/industry or they are at least a little obsessed.