I have helped several folks without degrees successfully interview at CAL, and a whole bunch at JetBlue. It is HARDER to get the call, but with a nudge or push from a good sponsor its not impossible.
Most of the folks I have helped without a degree have gone on to do some pretty cool stuff...they weren't exactly "slackers". Life just threw them a curve and they took an alternate route. Once recent guy actually started a business, built a factory, then sold the business for several million dollars THEN chased his dreams of flying.