As a guy who recently went from a good Part 91 corporate job to Fedex, it can be done.
There were a couple of reasons why I left, but primarily the main reason I left is for the stability. I can't tell you how many times I flew with contract/part-time pilots who were 50, 55, 60 years old, who all had basically the same story (laid-off, fired, quit, dept closure, etc....). For me, I couldn't see myself at their age in the same situation (not that it would have happened, but I believe the chances are much greater in corp than at fedex). Also, it certainly doesn't get any easier to land a good corporate job the older you get.
Most of these guys were previously making big bank, working for top end companies, flying top of the line equipment and yet were turned over for some reason or another, and therein lies another problem with the corp world, things can change overnight. Whether it's a CEO, General Counsel, VP, Chief Pilot, etc, all it takes is one person/attitude/event and the entire flight dept can change dramatically (no corporation is safe from this).
Z-