never flown the B200 but
I have 1500 hrs in the B350 and I really like it. We fly it 90% of the time as a 2 pilot airplane, it IS busy with TAWS, TCAS, the FMS, ATC yabbering at you, and oh yeah, you are looking outside and flying the airplane. So that co-pilot is really nice.
It is my understanding that most insurance companies want two pilot crew in the 350 anyway.
It "likes" FL 250 to 280 the best, altho it will do FL 350. Plan on about 550 mas/menos lbs total fuel flow at cruise flight, and flight plan for 260 knots. Raytheon brochures and the local Top Gun will claim 280, however, real world, 260 works all the time.
Plan on 4.5 between fuel stops for conservative and safe practice. Yes, yes, we all know it will do more, with the winds in your favor and the stars lined up just right and the power levers set perfect, but 4.5 hours will land you with 400 a side (1 hr+) and keep your blood pressure down.
Vref is 105 at max gross
it will carry 8 pax plus full fuel (3600 pounds) from most strips in most conditions most of the time. Something to be said for that.
I personally have taken them into and out of La Paz, Bolivia, Bogota, Colombia, Toluca, Mexico, and Juliaca, Peru. These are obviously amongst the highest airports in the world.
the ones WITH strakes and wing lockers are a little slower in cruise and a little doggier in climb than the "clean" airplanes
alot of the "new guys" in the 350 coming up from Navajo or 421 type airplanes forget to pull power after takeoff and when ATC gives them a "maintain 3000 for now". Freakin airplane will punch thru 250 knots before you know it.
easy rule for "Class B-D" areas is 40% torque/props 1500 and this will always give you 170 knots, which is good for mixing in with airliners and not completely running over the Mooneys out there
single pilot type is indeed a MOTHER F**CKER but you can do it, get your mind right, its just a big Seneca with EFIS and PT-6s and pressurization (!!)
good solid airplane
good luck