Enjoy the 25! Hopefully you've got the -8 GE's which are nice. Rick and G200 gave you some excellent advice, here's my two cents worth:
Plan on a fuel burn of 2200 the first hour, 1800 the second and 1500 the third. Avoid if possible airports like ADS and PDK where the tower controller is going to make you wait for your release. Those General Electrics burn more fuel on the ground than they do at high altitue cruise. Taxi out on one.
Negotiate actively (Read that beg shamelessly) with ATC. Tell them you'll give them a great rate if you can continue the climb. Avoid leveling off at all costs on the long legs. Beware of the Northeast, Florida and anything around Michigan, Ohio, Indiana and Illinois. (Airspace geometry will dictate a descent clearance MUCH sooner than you'd prefer.)
To pile on G200, never, ever, EVER, vacate cruise until you're sure the airport is open and the WX is cooperating. Once you start down, the circle in which you can land land gets MUCH smaller. (At the end of a three hour flight it wasn't that big to begin with...)
The jet has wonderful controls. The ailerons are much crisper than the 30 and 50 series. One word of caution on that wing though, don't fly it much below Vref. Aim to touch down at ref. Bad things can happen on those older wings if you allow them to get too slow.
During the descent maintain 80% or more RPM or your cabin will start to climb. Once below FL200 you can go to idle. In the climb, I always used 98% or 680 degrees, whichever comes first.
The J.E.T. 150 aotopilot sucks. Don't trust it. You're flying an aircraft with a pretty healthy thrust/weight ratio. Pay attention when your're IMC, the scan is a bit faster than other Lears. Be especially vigiallant during go-arounds in IMC. Nail the pitch attitude and fight the somautogravic sensation/illusion. (Spelling?)
Fun airplane man, let us know how you like it. If you need any more lame advice, feel free to drop me a line.
Cheers!