People with difficult commutes typically bid and average 5 days on, 5 days off. Our preferential bidding system makes that pretty easy to get, even if you are junior. You just can't be too picky about what kind of trips you fly if the dates are the most important. As you gain seniority, it's not too difficult to get 4 days on, 6 days off. You can expect to fly pretty close to 29 hours in those 4 or 5 days on so you can get all your flying for the month in 3 cycles.
We have a couple of people with REALLY ugly commutes from as far away as Alaska. They bid trips with duty rigs and 24+ hr layovers that allow them to get 15-16 days of flying in a row and then home for 2 weeks. That way they can get the minimum block for pay without exceeding 30 in 7 limitations. If you live near Long Beach or Oakland, that will not necessary.
We have lots of people who commute from the West Coast. If you live near Long Beach, the commute will be long, but it won't be as painful as a two-leg off-line commute that many of us endure. The frequency of flights, including redeyes, gives you lots of options. Anybody who lives near a blue city will find the commuting life much easier than those of us who are in the Midwest and not close to anything blue.