Temporarily, it might be OK....... Long term NO!!!!!!!
I commuted for 10 years from RSW to: JFK, PHL, CVG, MDW, HOU, DAL and PHX. 8 years of it was offline, often more than 1 leg. It absolutely killed me. Many times, I'd walk in the door after 20+ hours of being awake. The absolute best time for a commute was about 6 hours, but that was just making the flight home (home is where the car is). Going to work depended on a lot of things, not the least of which was the ever changing RSW airline service. I could rarely use the same flight to commute. Airlines would change their schedules, or completely stop service for a while. It was crazy. The best commute to work was on ATA to MDW, and even that was kind of a pain, because they changed their schedule so often (great people though.......). I was leaving at 10:00 in the morning the day before I worked to catch the only nonstop up there, because the alternative was to leave my house 2 hours later, and get to MDW 6-8 hours later.
The easiest airplane commute I had was driving 100 miles to FLL to commute on my own airline, one leg to MDW. I was spending an extra 4 days/nights a month away from home, in a crash pad no less for no extra pay. It really adds up to a negative QOL.
Now I drive 3 hours, and it is by far the easiest I've ever had. I live in Naples, FL, which by most accounts, is a nice place to live. I absolutely HATE living here, due to the difficulties I've had getting to and from here/work over the years. If I could get my wife to move out of here, I'd have a 20 minute drive to work instead of 3-5 hours, depending on day/time of the week.......
If you have any reservations at all, reconsider commuting. As someone else has said, everyone has their own threshhold.