One of the biggest safety issues IMO for us corporate/charter guys is fatigue.
Typical scenario: O'Dark Thirty show time. Get into the destination around noon. Get a day room. Show back out at the airport 10pm for an 11pm departure. Get back to home airport at O’Dark Thirty.
I don’t know how some guys can do it, but I *can not* sleep during the day. On trips where we are required to get a day room, it’s not unusual for me to be shooting an instrument approach at night after being awake for 20+ hrs.