If I could do it over again I'd take out a loan, like I don't have enough already, and buy lots of twin time somewhere. Of course, I probably would have gotten my CFII/MEI too and that would have helped. (Runs head into wall)
I was fortunate to get the little amount of M.E. time I have now (whopping 114) at my last job by doing co-pilot stuff in King Airs and Citations, but all that got me was SIC time. I don't even know how that SIC time will help/hurt me when I look elsewhere.
Anyway, get whatever multi-time you can, because it seems most 135 freight outfits with twins want at least 200 M.E, and M.E. time is about the only way to get anywhere it seems.
I agree with Kingaira90 though, try to get your foot in the door in the 135 world however you can. I got on with my company with 1,195TT and passed my checkride at 1200.5 or so. Although I'm only flying a single-engine, at least it's turbine! PTL!
Good luck, Bud!!