I only have firsthand experience with the A320 and the B757 so can only compare the two.
In general, my ideal single-aisle airliner would be the B757 Rolls-Royce engines, wing and brakes mated to the A321 fuselage and flightdeck, systems design philosophy, fly-by-wire with sidesticks and engine FADEC's.
Specifically:
Flat floor w/o seat tracks that try to twist your ankle and rip the heels off your shoes. You can also spread a blanket on the carpeted floor and sleep behind the seats on those long augmented out and back turns. Score one for the Bus.
Dark overhead panel philosophy with mostly flat pushbutton switches to minimize damage to your head if you forget to duck. Great human factors engineering with flow lines for systems. Score one for the Bus.
Much better design on cup holders, pilot sunshades and side window shades on the A320. Score one for the Bus.
Sidesticks allow you to put the aircraft where you want it to go with just minute movement of the wrist. You do need to properly adjust your armrest. Score one for the Bus.
The tray. What can I say? It holds a lunch, a laptop and all the paperwork we still have to do flying internationally. You can cross your legs and spin around in your seat. Score a big one for the Bus.
The Intel 8086(or 8088) processor on the earlier A320's was way too slow. It was very easy to out-type the processor and just when you went to line-select a scratchpad entry, the waypoints would re-shuffle and your entry would end up on the wrong line. Also, the processor would only read the MCP every half-second making it imperative to verify the MCP entry on the FMA before moving on to other tasks. Even though both FMS's were made by Honeywell, the B757 FMS was less capable but more intuitive than the A320 FMS. FMS's have been greatly improved in later versions of both aircraft. Score one for the Boeing.
I personally preferred the conventional hydraulic steel brakes on the B757 to the brake-by-wire carbon brakes on the A320. I liked the feel and perceived effectiveness of the steel brakes better. Cockpit readouts of brake temperatures and brake fans for quick turns on the A320 were nice. Score a draw on brakes.
The IAE V2500 engines on the A320 configured for all-coach class(29 rows, 174 seats) weren't always up to the task for the passenger loads and stage lengths we flew. Had to make many bleeds/packs off takeoffs. Never had to do that in the B757 with either the RR or P&W engines. You can never have too much power. Score one for the Boeing.
The A320 was only certified to FL390 while the B757 was certified to FL420. That extra 3,000 feet was pretty useful when trying to stay out of the tops of Wx. Never any worries about the strength or lifting ability of the wing on the B757. Score one for the Boeing.
The fuselage diameter on the A320 family is 7.6 inches greater than on all the single-aisle Boeings. This allows each coach seat and the aisle to have an average of an inch extra width. There is more headroom and more room for overhead bins also. Score one for the Bus.
The A320 had vacuum lavs which were very noisy(hard to sleep in the back row on crew rest) and somewhat cantankerous but saved the weight of 5 gallons of blue water per lav. The B757 lavs hold 9 gallons of liquid each of which 5 gal. is fresh blue juice. Much quieter, heavier and often stinkier and always the possibility of a flush motor overheating. Vacuum lavs more suitable on a long-range aircraft ala B767 and B777. Score a draw on lavs.
Aesthetics. I don't think a better-looking airliner was ever built, with the possible exception of the Lockheed L-1049 Super Connie, than the B757. Score one for the Boeing.
And thats my humble opinion.