Active duty wise, I personally would choose AFSOC (Cannon) over ACC (Creech). I just think the Special Ops UAV missions are cooler. For most, though, location will likely be a bigger factor. I personally don't think Cannon (Clovis) would be that bad, but I'm in the minority.
On the Guard/Reserve side I don't think it really matters. All the ANG units are ACC and the lone AFRC unit (2nd SOS at Nellis) is under AFSOC. I think schedules and lifestyle are going to be similar at all UAV units. On the guard side, I think schedules are roughly 4 on/3 off with minor variations. Everyone will have to pull the night shift on occasion. At this time the deployments are minimal (unless you volunteer to do it). Unknown if this will change in the future.
I'm off to UAV training in January. Hopefully someone that is already active in UAVs can add some more info. UAVs are definitely getting more popular amongst the QOL crowd, hence more competitive.