A regional is a regional. They've all got their problems. If it's the only offer on the table, take it. Bide your time, there will more oppurtunities that arise. That's the intent of the regions. They want you to stay four or five years and leave.
I'll work for the airline I'm at until I can find another airline job or hopeful corporate gig where I don't have to commute. QOL is a big issue for me with family and commuting is the worst part of it right now. When I look at the all the issues presented at the regional level, I have a hard time really getting angry over it. I could be getting shot at in Ash-can-i-stan and deployed away from my family for a year at a time but instead, I fly planes that are air conditioned and stay in nice hotels with hot water. I missed Iraq both times but I've spent plenty of time in the field with no showers, stinking to high heaven, sleeping on the ground for only a couple hours when you find time and walking more miles than I care to count. It just ain't that bad, plus it beats working for a living.