Download and check your performance, then download again. Consider taking off light and going to Grand Junction for fuel, then heading out from there.
Your approach will look flat. It is. Don't be too flat. Don't go in there on instruments. If you can't see it, don't land there. That doesn't mean scooting in beneath the clouds after flying an approach to Telluride. It means a good solid visual approach. Especially if it's your first time. Don't count on great performance when going missed or going around, and though Telluride doesn't look it, it can be a one way strip. It can sucker you in.
The runway goes downhill, then uphill again. When you think you have it made, it keeps dropping away from you, resulting in landing long and fast...which the uphill end helps make up for. When taking off, just when you think it's time to go fly, the runway climbs up toward you. You get instant altitude off the end if you need it, but you have to clear the fence at the end...which has caught folks unaware before.
Be sure you don't compromise yourself with frost on departure. Be sure you have a slot and room to stay if you're planning on that. Plan on realistic alternates, especially if you're used to flying in the East. Alternates aren't as plentiful, and may close down quickly. Consider Grand Junction or Montrose.
Take a good look at your single engine capabilities. You may not have much of a choice if you lose an engine, and if you lose one going in, you may have no choice but to get it right on very marginal performance. Be prepared for rapidly changing conditions.
Landing at Telluride isnt rocket science...if you fly sensibly and know your performance, you'll be fine. If you get ice and can't shed it, you can't go down to lower to find warmer; there's terrain in the way. Same for executing a missed approach on limited performance, and definitely don't go hunting for the runway or airport with low conditions. It's a little hard to spot unless you know where it is, unless you're well above it. If you come have a look high, you can set up and come back around...but give yourself adequate ceiling and visibility to do it. If the weather is down, rather than push yourself, be prepared to land at Grand Junction of another choice and drive up in a rental car. Good luck.
