Mason,
Put these in just one forum. One is enough.
Not enough information is provided. For what purpose do you intend to remove the seat? Who will remove it? Under what regulations are you operating (eg, 91 only, 135, etc)? Under what airworthiness limitations are you operating (restricted category, etc)? Is this a revenue flight? Does the aircaft have a MEL? What do you intend to put on the floor, if anything and have you investigated the load bearing limitations applicable too the floor area without a seat? (can you legally walk there?). Will you be retaining the flight controls in that position, and if so, what is done to protect them? Will cargo be carried which could interfere with the flight controls?
Are you asking if you can remove the seat, or if you can operate with it removed?