You can have a non-aviation career outside the Guard/Reserve. It's easier on the non-rated types (like me) who don't have to be away from home much for manadatory training in addition to being away from home for the airline job.
When I retired from the Guard, my wife was thrilled. Not only did she have me home for an extra two days, but she didn't have to "share" me with the Guard. When I was a company commander, it did take a lot of time away from her. Fortunately, I gave up command before my first child was born.
A friend of mine (airline pilot) flew C-130s in the WVANG. He had a hard time scheduling his mandatory flying with the unit because he was on reserve. On his hard days off, the only thing available was a "parts run(his words...not mine!) between Dover and Martinsburg. The airline line-holders in his unit were easier to schedule, as were the non-airline types, who were reliable for extra weekends.
If you are a government employee...watch out! Federal, state and local government agencies were the worst when it came to get time off for mandatory military training. As a commander, I had to deal with various government agencies when they gave my soldiers a hard time about military leave. They didn't take kindly to my telling them they were subject to the same leave rules the private sector had to deal with concerning military leave.
Good luck...fly safe!