MPTO is pretty straight forward, no surprises, handling is OK, if a little on the slow side, they do have a tendency to dissapear and leave you stranded on the exec ramp but eventually return. Be sure to wear full pilots uniform with epaulets, etc as it makes getting back through security a lot easier.
I stayed at the Panama Marriott, which is excelent, centrally located and within walking distance of many good restaurants. Just be sure to observe common sense precautions when going out. There aren't any beaches in Panama city, but a trip to see the Mira Flores locks at the canal is worth while as well a trip to see the old city. If you have enough time (which I didn't) you can arrange a tour to see the rain forest.
Have fun!