I would think the question would really be "Do you want to make a career at a so-called "regional" airline?"
If so, go to a place like Skywest or AE.
If you want to work at SWA, Alaska, Frontier, Airtran, ETC, go get a quick upgrade and start getting Turbine 121 PIC time.
I guess its all about getting that seniority number at the airline you hope to retire from, hopefully making it possible to stay there with minimum furloughs!