I have spent 2 years on the 727 panel, and just got a bid onto the DC10 panel.
It's true that I've been able to hold hard lines (the crap ones) since Dec 2002, and by jumping to the Deisel 10 I will be A reserve until I get back off it. But it's like others have said here: our good trips are the best, but our bad trips are incredibly bad - worse than I ever saw at the commuters or ACMI.
(Speaking of 24 hour layovers, my record is 5 in a row. By the fifth one, I was sleeping 3 hours in a row max. It took me 4 days at home to feel human again.)
And as for bidding your home town - it's like the sasquatch. Everybody's heard of it, but few have seen it. For me to hold the 72 panel in my hometown (MOB), I'd have to have at least 5 years seniority, AND the 4 guys who hold it now would have to bid off the seat. That's alot of pipe to lay, just for the off chance that the Airbus won't take it over by the time I can hold it. Then there's the chance you may get "optimized", like Birmingham - Grand Junction was.
I guess the attraction is the thought of 2 weekend layovers in your hometown every month. But more and more stations have Saturday and Sunday mail flying. Go into ops on a Sunday afternoon, and there's as many pilots there as Monday at midnight. So what you do is get into the outstation Saturday morning, then fly back Sunday morning for the noon sort, then back out, then leave Monday night. You get Saturday day there (after you wake up) and Monday day there, but your circadian rhythm's a pretzel.
I've finally decided to just bid for the money. I ain't got time to stay poor and hope the lifestyle gets better. Flying for Fred means great pay, great crews, great aircraft; but training is used as a disciplinary tool, lots of trips are quite painful, and be prepared to fly nights, but not every night, just enough to seriously mess with your body. 25% of us will medical out before 60 - that says it all....