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Only if it hasn't been sent to ATC (or Flight service) yet, usually an hour prior to filed departure time. (Less than anour, they get forwarded immediately). There's the flight plan list, stored by your N-number, that you can edit or delete prior to that hour, but, after, if the plan is not listed there, it's already been forwarded, and there's no way to change it from DUATS that I know of.