It all depends on what type of lifestyle you're looking to have.
True, in 20 years with a major, you'll enjoy the 'lite' schedule, large paycheck, etc. However, in 20 years, how many of those years have you been away from home and family? Friends I have at the regional level flying roughly 90 hours a month (give or take a few) are spending nearly six months on the road. Compare that to a typical corporate flight department where you may spend 75-125 nights away.
Also true, at an airline you'll have a schedule. However, you don't always have to work for a Fortune 500 company to get a schedule. Granted, you probably won't get a months notice on what you'll be doing, but what is wrong with a week or two notice? I've worked nearly 15 years for privately held corporations and I've never carried a pager or been required to have a cell phone. In that time I've been called at home TWICE for "pop-up" trips. Most often, I know my schedule one week in advance which is plenty for me as the only time off I'm really looking foward to is vacation, which I have some control over when I request time off. Many corporate departments will work with you on other time off when needed.
Another truth, there are some corporate departments I'd advise you to stay away from. However, I bet there are some airline pilots that will advise you which airline you should avoid. It plays both ways.
Personally, I feel a corporate job would give you a much better QOL than that of a regional pilot. As a corporate pilot, while I go to many of the same places througout the year, I also go to many new places. I'm not stuck flying ABC-XYZ, DEF-UVW all month long.
A relative of mine, an FO at a major, once told me that if I chose the airlines I'd better prepare for atleast one furlough in my career. Since giving me that advise, he has been through one furlough, one airline shutdown and if he weren't retiring in less than a year, probably face another furlough at his present airline. I'm fortunate enough to work for a corporation who has had an aircraft for nearly 50 years. Granted, no job is certain, but I'd bet they'll have one for another 50. Argue if you wish, but I'm sure hundreds of Braniff, Eastern, TWA, etc., pilot's thought they'd be employed there forever too.
In a nutshell, do whats best for YOU and never look back and say "I wish I had..." I never look at "what might have been" because I control what was and, hopefully, what will be.
Fly safe!
2000Flyer