The c425 is a heck of an airplane. They preform so much better than the c421, That's obvious. However, the 421 is a good airplane. It really depends on how much you want to spend. The Conquest is a much better airplane but costs are a lot higher. Insurance, fuel, maintnence, etc. are more because of the turbines. The airplane is so much easier to fly than the 421, which also is an easy airplane. The main reason being the turbines. You HAVE to baby the geared engines, or they will fail quick, fast and in a hurry.
A couple of quick points: if you go with the 421, be sure to get the C model. They don't have the tip tanks and they do have the trailing link landing gear. Not nessesities, but make it much nicer of a ride. Also, be sure to get one that has the spoilers installed. They make it much easier on the engines when it is time to come down.
If you go with the Conquest, look at getting one that has had the Blackhawk engine mod done. They make a good airplane even better.
Aside from the engines, the 421 and the 425 are essentially the same airplane. There are little diferences like the nose and the horizontal stabilizer. A 421 will run you about $500,000 for a good C model. The B model will go for 250-300,000. A Conquest will go for 1-1.2 million, depending on equiptment. The Blackhawk 425 will go for not much more.
For the price of the 425, you can get a Kingair. Maybe even a 200. They have a ton of room and are good airplanes. However, they are going cost more to operate.
This is my two cents, hope it helps.