I started at Ameristar last year with around 2000TT, 600MEL, and 435 turbine. We have guys here who came straight from flight instructing with just over 1200TT and others who came from the regionals with 3000+ hours. It helps to know somebody who works here to get hired with low time, but sometimes we hire street applicants. Business is slow, so hiring is minimal right now.
If you wanna fly 135 jet cargo, you have to be a good pilot, you must have some guts, and be ready to operate in any conditions with 40 year old airplanes. If you're not all of these things, you will be a burden to the captain and the company.
You have to know how to fly NDB approaches and DME arcs to VOR approaches, and shoot them down to minimums, at night, surrounded by mountains, into airports you've never been to before...and you have to do it frequently.
You will fly through Tstorms at FL410, you will land on icy runways, you will fly with INOP equipment, and you will have to load freight in the freezing rain. This job is not for the faint of heart.
We have no TCAS, no GPWS, no TAWS, and there's no fancy FMS in our airplanes. Our GPS' are from the early '90s. There is no moving map. There is no terrain mapping.
Sometimes the auto pilot decides not to work, so you will have to hand fly the airplane for two hours at 43,000ft.
If you are married, don't apply. If you have children at home, don't apply. If you have pets living with you, don't apply. You will be away from home a lot.
On the up side, you get to fly a Learjet that can climb over 10,000fpm. You get to do the fun type of flying that you will never experience in an airline job. You will visit places you've never been before (some you may never want to visit again, lol). At our company, you will make over $30,000 first year salary. If you upgrade, you'll make over $50,000 second year. You may not like the job, but at least you'll make enough money to enjoy your life outside of the job.
In my opinion it's better to be able to enjoy my home life than it is to enjoy my job. If you are independently wealthy or still have your parents paying your bills, then maybe a regional job is better for you.