Erlanger
You are sadly wrong. ATC has run "double shifts" for 30 years now, and Comair goes to the wrong runway and it is ATC's fault? Sure, two controllers might have prevented it, maybe so, and maybe not.
It was a unfortunate accident...Captain probably taxied to wrong runway, while FO is heads down on the box and looking at charts and paperwork. Captain reaches the end of the incorrect runway, tells FO, "your plane", who looks up and applies power, with tragic results. Thats prob what happened, but I do not know. Lets wait for the NTSB report.
As far as the Lear crash, that crew
1) Did not fly the recommended DP
2) Did not obtain IFR clearance and departed in hilly terrain at night, VFR.
3) Forgot that under VFR, terrain and collision aviodance is 100% the pilots responsiblity, even under positive radar contact and control, such as flight following. The PIC still MUST monitor the controller and flight.
4) Did not brief the departure nor terrain in the area. Worst case scenario, they takeoff from the other direction and that makes it safe(r).
Not to second guess two dead guys, God rest their souls, and like you said, lets all learn from this. Me personally, I am more concerned with physical terrain avoidance then I am about busting a stratus layer while still under VFR control. I know how to fly by instruments.
I have seen more accidents because pilots were wrapped up in "we don't have an IFR clearance yet" and scud runned until they got one, when they could have just orbited up and above the airport until above the MSA. Of course the preference is don't fly into IMC without a clearance. But if you are gonna launch, don't get killed if you don't really have too.
The NTSB report stated the bases were 2100 at the airport. The MSA circle for the SW quadrant is 2500 feet
http://myairplane.com/databases/approach/pdfs/05814VGA.PDF
Airport elevation is 524, putting the turbine traffic pattern at 2024, or basically in the bases. Cognizant of an airborne IFR pickup, one alternative would be to depart RWY 26, headed toward flat terrain, and flown a 1000 foot pattern, while waiting on ATC. You would wake up the neighbors, but at least you aren't headed towards the mountains at night.
Again, we could second guess and say "I would have done ____" to these now-dead fellow aviators all day long.
With that said, if you insist on departing VFR into IMC, have a gameplan to deal with it, and that does not mean scud-running. It it means busting a cloud layer to avoid granite rock, well, I know choice I would make....