Twin pros and cons
You usually have two of everything on a twin.  Two alternators, two fuel pumps, etc.  Hopefully, and more importantly, two vacuum pumps.  In other words, double the worries.  Bad fuel in a twin and you lose both engines.  The average light twin glides like a rock.  You can always install an auxilary vacuum pump on a single
A big misconception about a light twin is more safety.  Notwithstanding twin-engine operation concerns, e.g. flight near Vmc, losing an engine means you buy time to maneuver for safe off-field landing, if you're not near an airport.  I remember how we practiced engine-out procedures in our Seminoles at ERAU-Prescott.  It was amazing how quickly we lost altitude.  Of course, bad technique made it worse.
Lose one on takeoff and maybe you can struggle up to altitude to fly a full pattern to land.  On a hot day, you may again get more time for that off-airport landing.
Speed depends on the airplane.  I recall that an A36 Bonanza cruised almost as fast as a Seminole.  I also recall that our retractable Skylanes had a high cruising speed.
Even with the possibility of losing two of everything, the percentages of that are remote.  I'd say a lot depends on the mission, but, you're probably safer in a twin that is operated safely and properly.