The overal QOL is better than most regionals. No contract is perfect and if you ask 100 Mesaba pilots from all bases and status (CA and FO), lineholder, or reserve line, you'll get 100 different answers.
Just be prepared to do lots of 4 day trips, followed by another 1 or 2 day trip. Some lines though have lots of 1 day trips, and like Othello said, QOL is much better if you live at base. commuting sucks, no matter where you commute from, even if it's just a 15 minute flight.
If/when we start receiving new airplanes, I think QOL will be much better.