Yea it's a real $hitty airframe....Hauls 100,000 lbs across the North Atlantic non stop.
When IB used to fly them out of ORD they rarely made it without stopping in Gander, even EI had to stop on occasionally if they were heavy.
Weight isn't generally much of an issue when you can't fully utilize the cube of the aircraft because of the dimensions on the ULD's. I can't think of many operators that weight out before they cube out going to Europe on their freighters (density finds its way to the bellies of the passenger flights, crap goes on the freighters).
Could be the greatest plane to fly and make tons of $$$ for the small package guys. On the heavyweight side though there wasn't a lot of love for them.