As one who commuted for awhile, now does not, but flies with many who do, here is my advice:
- Don't commute if you reasonably cannot--as posted ad nauseam
- If you have determined that you will commute for the foreseeable future--accept that you are a commuter and the added time away that that entails. Those who are the happiest commuters are NOT the guys (and I was one of them) who always bid commutable trips, waking up at 4 am so that they can take the 6am flight (which of course is their backup flight), arriving at domicile at 730-8am for a 1500 signin. Don't be a "last flight chaser" either, in which you are hoping for a 15 minute early arrival so that you can race to the gate (asking the other guy to please take your flight kit to the pilot lounge) and just make the last 1030pm flight to get you to your home city at midnight and your home at 0130.
- Those who are the happiest commuters don't race for airplanes, sweat early arrivals, or obsess about 0400 wakeups to make the 0600 flight--they are the guys who if they have a 0700 sign in, commute the day prior, accept the fact that they will be gone from home a bit more, and enjoy a nice evening in their crashpad or airport hotel, reading the paper or getting a good workout in. Similarly, they may indeed make it home the same day as their last work day--but if they do not, they just get a good nights' sleep at aforementioned crashpad/hotel and leisurely go home the next day.
ALL of the above requires an understanding spouse for the married pilots, but I can assure you it is worth it in peace of mind and lack of stress.
I would say that if your home life dictates that you MUST do same-day commutes on both halves of your trips, then you should not commute.