Ditto Bassethound with a few additions.
I can't speak for other MWS's, but in C-130's at least the Guard/ Reserve generally get better JAATT locations (sorry, too many acronyms... A JAATT is a trip lasting anywhere from one day to 2 weeks). While Active duty guys spend a lot of time going to Pope, Ft Benning, Yuma, and other such places; the ANG/AFR are going to Puerto Rico, Venezuela, Hawaii, Australia, etc. Additionally, in C-130's, most ANG/AFR units have newer aircraft than active duty (90's vintage versus 60's models).
As far as active duty benefits vice ANG/AFR, there are a few things (some can be good or bad depending on your preference). You will have more opportunities to live overseas in various locations to include possible exchange tours with foreign countries. Correct me if I'm wrong anyone, but I think you can start collecting retirement at a younger age from active duty. You will have more opportunity to crossflow from one type of aircraft to another (ie tankers to airlift, anything to U-2's, between airlift types, etc.). There are usually more objective criteria for getting on active duty (good ol' boy network doesn't hold as much sway). You'll work closely with a lot more people from different backgrounds (constant personnel turnover, not drawn from one geographic area). Some MWS's have a shorter uprgrade time to Aircraft Commander in active duty. Everyone's active duty all the time, so there's no added burden on certain people to get non-flying type things accompished (I have heard from some of my AGR/ART buddies that they will sometimes get stuck doing extra queep because part-timers don't have the time to do it). You don't have state politics in addition to national politics to contend with........well, that's all I can come up with off the top of my head......anyone else care to chime in?
Hey, Bassethound, is O'Connel still down there?